Christina Applegate is PEOPLE's Most Beautiful

PEOPLE Magazine unveiled its annual Most Beautiful issue today, with Christina Applegate on the cover.

The "Samantha Who?" star says she "started to come into my own in my late 20s and early 30s."

According to the interview, part of Applegate's confidence stems from her battle with breast cancer last year. Applegate had a double mastectomy but thankfully didn't need chemotherapy or radiation.

Twitterers raved about the decision:

1. 
   MsRumsey Congrats to Christina Applegate, cover girl on People Mag's 100 most beautiful. Its true.
2. 
   stacia_naquin People's "Most Beautiful" list came out today. At the top of the list -- Christina Applegate. Good choice People Mag!
3. 
   kathrynzj Try to stay away from celeb drivel but props to @peoplemag for naming Christina Applegate most beautiful.
4. 
   Rkeps Love Christina Applegate! She definetly belongs on the cover of the 100 Most Beautiful issue of PEOPLE mag.
5. 
   KellyWinnFM christina applegate is people's most beautiful this year, so cool
6. 
   jackalackin Christina Applegate is the People mag most beautiful person. I wish they would have used a Kelly Bundy era pic, though.
7. 
   rosenfie Really glad to see Christina Applegate on the cover of People's 100 most beautiful. Good for her!!
8. 
   ashthompson Is usually love Perez, but labelling 'People' naming breast cancer survivor, Christina Appelgate, most beautiful a travesty is not cool!!

Kate Hudson graced the cover of last year's Most Beautiful issue.